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Fig. 2 | Genome Medicine

Fig. 2

From: Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

Fig. 2

Mutational signatures and homologous recombination deficiency scores within MPM. A The number of single nucleotide mutations contributing to each single base substitution (SBS) somatic mutational signature within each patient that was identified using COSMIC v3 signatures. The major common categories are grouped together using similar colours. B The number of indel mutations contributing to each indel signature within each patient. Somatic indel mutational signatures estimated from indels with a size of 1 to 50pb and compared to COSMIC v3 signatures using cosine similarity. C The number of SV mutations contributing to each rearrangement signature within each patient. D The HRD-sum score for each patient. The dashed line represents the threshold for HR deficiency. E The HRDetect score for each patient. The dashed line represents the threshold for HR deficiency. Sample and patient features are shown below the plots

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