Fig. 3

Overview of genomic alterations in driver genes of MPM. Genes are shown if they were identified as significantly mutated, have recurrent promoter mutations, were present in GISTIC analysis or contained a high number of breakpoints. A Somatic SNV and indel mutations across three cohorts. The colour bar at the top indicates the sample cohort: Creaney et al. (purple), TCGA (pink) and Bueno et al. (light blue). The histogram shows the number of mutated driver genes in each sample. The oncoplot shows the mutations in each gene. The number of samples with mutations in each gene is shown in the bar chart on the right. The type of SNV or indel mutation is shown using colour codes. B Analysis is restricted to the samples in the Creaney et al. cohort which underwent WGS. The histogram shows the number of mutated driver genes in each sample. The oncoplot shows the SNV and indel mutations, breakpoints and copy number alterations in each gene. The order of each gene is the same as in panel A, and the sample labels are along the bottom. The mutation type is shown using colour codes