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Fig. 4 | Genome Medicine

Fig. 4

From: Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

Fig. 4

Neoantigen load derived from SNV and indel mutations in MPM. Predicted total neoantigen load derived from SNVs and indels with IC50 ≤ 500 nM in the A Creaney et al. cell line, pleura and pleural effusion samples and B TCGA pleura samples. Pearson correlation plots between short nucleotide variants (SNVs) on x-axis and neoantigen load on y-axis for C Creaney et al. and D TCGA dataset. E Boxplots for predicted total neoantigen load (IC50 ≤ 500 nM) (y-axis) in Creaney et al. cell line, pleura and pleural effusion samples and TCGA pleura samples (x-axis). F Boxplots for expressed neoantigen load (IC50 ≤ 500 nM) in Creaney et al. samples and TCGA pleural samples. p-values shown are from Wilcox test

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