Fig. 6

An overview of key mutation processes and the tumour microenvironment in MPM. Inhaled asbestos fibres located at parietal pleura of lung. Asbestos fibres may trigger cell damage and contribute to initiation of mesothelioma cells. Whole genome sequencing of mesothelioma samples revealed 13 candidate driver genes and mutations were enriched with SBS40/5 mutation signature. Whole transcriptome sequencing identified ‘hot’ a TME marked with the presence of T cells and cytolytic activity in a subset of samples. The majority of MPM favour the growth of the tumour cells by promoting a "cold" TME comprised of M2 Macrophages and TGFB1 expression. Figure created with BioRender.com