Fig. 2

Effect of the BRCA1/2 mutation carrier states on estradiol and progesterone levels during menstrual cycle progression. Estradiol and progesterone hormone levels were significantly greater over one cycle in BRCA1/2 mutation carriers (n = 12) than in controls (n = 8): a and b show the time-series (respectively) for estradiol and progesterone (normalised by cycle length) with one-week moving average lines. c One-week moving windows (as used to plot the moving average lines in a and b) were used to assess how the relative increase in hormone levels in BRCA1/2 mutation carriers (compared to controls) varies during the cycle. All significances were assessed with t-tests