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Fig. 5 | Genome Medicine

Fig. 5

From: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Fig. 5

Effects of vitamins (placebo/comparator), mifepristone and ulipristal acetate treatment on intermediate cancer surrogate endpoints in normal breast tissue from healthy women. The impact of Vitamin (ac), Mifepristone (df) and Ulipristal acetate (hj) on the mitotic age index WID-Breast29 (a, d, h), luminal progenitor cell fraction (b, e, i) and basal cell fraction (c, f, j) in healthy, unaffected women at lower and higher breast cancer risk. g RANKL mRNA expression before and after treatment with mifepristone (as assessed by real-time PCR). k Correlation of the change in WID-Breast29 index with the change in breast epithelial subtype fractions in all samples in a–f, h–j. All significances in a–j were assessed with the paired-sample t-test. Significance in k was assessed with Pearson’s correlation test. Gold lines indicate increasing and blue lines decreasing values from the breast biopsy taken before to biopsy taken after treatment

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