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Table 1 UVMR analyses of 37 clinical factors on CAD

From: Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

Category Clinical factor (abbreviation) SDa OR (95% CI) per SD incrementb
East Asian European Meta-analysis
Cardiometabolic Height 9.3 cm 0.86 (0.81, 0.92) 0.85 (0.81, 0.88) 0.85 (0.82, 0.88)
Body mass index (BMI) 4.8 kg/m2 1.67 (1.48, 1.89) 1.38 (1.29, 1.47) 1.44 (1.36, 1.53)
Fasting glucose (FG) 21.82 mg/dL 1.41 (1.20, 1.67) 1.17 (1.05, 1.30) 1.23 (1.13, 1.35)
Hemoglobin A1c (HbA1c) 0.60% 1.37 (1.24, 1.52) 1.21 (1.12, 1.30) 1.26 (1.19, 1.34)
Type 2 diabetes (T2D) - 1.13 (1.08, 1.19) 1.08 (1.05, 1.12) 1.10 (1.07, 1.13)
High-density lipoprotein cholesterol (HDL-C) 14.80 mg/dL 0.89 (0.78, 1.02) 0.89 (0.80, 0.99) 0.89 (0.82, 0.97)
Low-density lipoprotein cholesterol (LDL-C) 33.63 mg/dL 1.77 (1.50, 2.09) 1.82 (1.61, 2.06) 1.80 (1.63, 1.99)
Triglyceride (TG) 90.68 mg/dL 1.44 (1.08, 1.92) 1.27 (1.03, 1.57) 1.32 (1.12, 1.57)
Total cholesterol (TC) 44.21 mg/dL 1.67 (1.37, 2.04) 1.25 (1.10, 1.41) 1.35 (1.21, 1.50)
Systolic blood pressure (SBP) 18.67 mmHg 1.68 (1.36, 2.08) 1.96 (1.70, 2.26) 1.87 (1.66, 2.10)
Diastolic blood pressure (DBP) 10.14 mmHg 1.79 (1.44, 2.24) 1.85 (1.55, 2.21) 1.83 (1.59, 2.10)
C-reactive protein (CRP) 0.44 mg/dL 1.16 (0.83, 1.64) 1.02 (0.92, 1.14) 1.03 (0.94, 1.14)
Hematological White blood cell count (WBC) 2134.64/μL 0.94 (0.81, 1.07) 1.00 (0.93, 1.07) 0.98 (0.92, 1.05)
Lymphocyte count (Lym) 1191.27/μL 0.84 (0.67, 1.05) 1.05 (0.97, 1.14) 1.02 (0.95, 1.10)
Monocyte count (Mono) 276.57/μL 1.31 (1.07, 1.59) 1.01 (0.94, 1.08) 1.04 (0.97, 1.11)
Neutrophil count (Neutro) 1416.78/μL 0.97 (0.86, 1.11) 1.02 (0.93, 1.12) 1.01 (0.93, 1.08)
Eosinophil count (Eosino) 136.22/μL 0.96 (0.89, 1.04) 0.95 (0.87, 1.05) 0.96 (0.90, 1.02)
Basophil count (Baso) 51.73/μL 1.06 (0.76, 1.47) 1.17 (0.68, 1.99) 1.08 (0.82, 1.44)
Platelet count (Plt) 5.99×104/μL 0.95 (0.88, 1.02) 1.04 (0.99, 1.09) 1.01 (0.97, 1.05)
Red blood cell count (RBC) 40.94×104/μL 1.21 (1.10, 1.33) 1.06 (0.98, 1.16) 1.12 (1.06, 1.20)
Mean corpuscular volume (MCV) 4.41 fL 0.98 (0.92, 1.04) 0.98 (0.93, 1.03) 0.98 (0.94, 1.02)
Mean corpuscular hemoglobin (MCH) 1.84 pg 0.98 (0.91, 1.05) 0.98 (0.92, 1.03) 0.98 (0.93, 1.02)
Mean corpuscular hemoglobin concentration (MCHC) 1.07% 0.99 (0.81, 1.21) 0.81 (0.66, 1.00) 0.90 (0.78, 1.04)
Hemoglobin (Hb) 1.23 g/dL 1.28 (1.11, 1.47) 1.16 (1.03, 1.32) 1.22 (1.11, 1.34)
Hematocrit (Ht) 3.53% 1.31 (1.16, 1.48) 1.22 (1.09, 1.38) 1.27 (1.16, 1.38)
Hepatic function Total bilirubin (TBil) 0.26 mg/dL 1.03 (0.98, 1.08) 0.99 (0.94, 1.04) 1.01 (0.97, 1.04)
Aspartate aminotransferase (AST) 10.60 IU/L 0.99 (0.76, 1.29) 1.03 (0.92, 1.14) 1.02 (0.92, 1.13)
Alanine aminotransferase (ALT) 14.16 IU/L 0.69 (0.47, 1.04) 0.96 (0.75, 1.23) 0.88 (0.71, 1.08)
Alkaline phosphatase (ALP) 26.45 IU/L 0.99 (0.88, 1.12) 1.04 (0.96, 1.12) 1.02 (0.96, 1.09)
γ-glutamyl transferase (GGT) 42.18 IU/L 1.14 (0.95, 1.37) 1.08 (1.00, 1.16) 1.09 (1.01, 1.17)
Total protein (TP) 0.40 g/dL 1.07 (0.97, 1.18) 1.03 (0.94, 1.14) 1.05 (0.98, 1.13)
Serum albumin (Alb) 0.26 g/dL 1.19 (1.02, 1.39) 1.14 (0.99, 1.32) 1.17 (1.05, 1.29)
Renal function Serum creatinine (sCr) 0.20 mg/dL 1.21 (1.07, 1.36) 0.93 (0.84, 1.02) 1.02 (0.95, 1.10)
Blood urea nitrogen (BUN) 3.90 mg/dL 1.13 (1.00, 1.28) 0.99 (0.88, 1.11) 1.06 (0.97, 1.15)
Uric acid (UA) 1.35 mg/dL 1.27 (1.13, 1.42) 1.02 (0.93, 1.11) 1.11 (1.03, 1.19)
Electrolyte Calcium (Ca) 0.38 mg/dL 1.01 (0.89, 1.16) 0.98 (0.87, 1.11) 1.00 (0.91, 1.09)
Phosphorus (P) 0.50 mg/dL 0.91 (0.79, 1.05) 1.02 (0.90, 1.15) 0.97 (0.88, 1.07)
  1. a SD of each trait among white-British participants of UKB. OR of CAD was reported on the same SD unit of each quantitative trait for MR analyses in both Europeans and East Asians. b For T2D, OR of CAD was reported per unit change on the log odds scale