Skip to main content

Table 1 UVMR analyses of 37 clinical factors on CAD

From: Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

Category

Clinical factor (abbreviation)

SDa

OR (95% CI) per SD incrementb

East Asian

European

Meta-analysis

Cardiometabolic

Height

9.3 cm

0.86 (0.81, 0.92)

0.85 (0.81, 0.88)

0.85 (0.82, 0.88)

Body mass index (BMI)

4.8 kg/m2

1.67 (1.48, 1.89)

1.38 (1.29, 1.47)

1.44 (1.36, 1.53)

Fasting glucose (FG)

21.82 mg/dL

1.41 (1.20, 1.67)

1.17 (1.05, 1.30)

1.23 (1.13, 1.35)

Hemoglobin A1c (HbA1c)

0.60%

1.37 (1.24, 1.52)

1.21 (1.12, 1.30)

1.26 (1.19, 1.34)

Type 2 diabetes (T2D)

-

1.13 (1.08, 1.19)

1.08 (1.05, 1.12)

1.10 (1.07, 1.13)

High-density lipoprotein cholesterol (HDL-C)

14.80 mg/dL

0.89 (0.78, 1.02)

0.89 (0.80, 0.99)

0.89 (0.82, 0.97)

Low-density lipoprotein cholesterol (LDL-C)

33.63 mg/dL

1.77 (1.50, 2.09)

1.82 (1.61, 2.06)

1.80 (1.63, 1.99)

Triglyceride (TG)

90.68 mg/dL

1.44 (1.08, 1.92)

1.27 (1.03, 1.57)

1.32 (1.12, 1.57)

Total cholesterol (TC)

44.21 mg/dL

1.67 (1.37, 2.04)

1.25 (1.10, 1.41)

1.35 (1.21, 1.50)

Systolic blood pressure (SBP)

18.67 mmHg

1.68 (1.36, 2.08)

1.96 (1.70, 2.26)

1.87 (1.66, 2.10)

Diastolic blood pressure (DBP)

10.14 mmHg

1.79 (1.44, 2.24)

1.85 (1.55, 2.21)

1.83 (1.59, 2.10)

C-reactive protein (CRP)

0.44 mg/dL

1.16 (0.83, 1.64)

1.02 (0.92, 1.14)

1.03 (0.94, 1.14)

Hematological

White blood cell count (WBC)

2134.64/μL

0.94 (0.81, 1.07)

1.00 (0.93, 1.07)

0.98 (0.92, 1.05)

Lymphocyte count (Lym)

1191.27/μL

0.84 (0.67, 1.05)

1.05 (0.97, 1.14)

1.02 (0.95, 1.10)

Monocyte count (Mono)

276.57/μL

1.31 (1.07, 1.59)

1.01 (0.94, 1.08)

1.04 (0.97, 1.11)

Neutrophil count (Neutro)

1416.78/μL

0.97 (0.86, 1.11)

1.02 (0.93, 1.12)

1.01 (0.93, 1.08)

Eosinophil count (Eosino)

136.22/μL

0.96 (0.89, 1.04)

0.95 (0.87, 1.05)

0.96 (0.90, 1.02)

Basophil count (Baso)

51.73/μL

1.06 (0.76, 1.47)

1.17 (0.68, 1.99)

1.08 (0.82, 1.44)

Platelet count (Plt)

5.99×104/μL

0.95 (0.88, 1.02)

1.04 (0.99, 1.09)

1.01 (0.97, 1.05)

Red blood cell count (RBC)

40.94×104/μL

1.21 (1.10, 1.33)

1.06 (0.98, 1.16)

1.12 (1.06, 1.20)

Mean corpuscular volume (MCV)

4.41 fL

0.98 (0.92, 1.04)

0.98 (0.93, 1.03)

0.98 (0.94, 1.02)

Mean corpuscular hemoglobin (MCH)

1.84 pg

0.98 (0.91, 1.05)

0.98 (0.92, 1.03)

0.98 (0.93, 1.02)

Mean corpuscular hemoglobin concentration (MCHC)

1.07%

0.99 (0.81, 1.21)

0.81 (0.66, 1.00)

0.90 (0.78, 1.04)

Hemoglobin (Hb)

1.23 g/dL

1.28 (1.11, 1.47)

1.16 (1.03, 1.32)

1.22 (1.11, 1.34)

Hematocrit (Ht)

3.53%

1.31 (1.16, 1.48)

1.22 (1.09, 1.38)

1.27 (1.16, 1.38)

Hepatic function

Total bilirubin (TBil)

0.26 mg/dL

1.03 (0.98, 1.08)

0.99 (0.94, 1.04)

1.01 (0.97, 1.04)

Aspartate aminotransferase (AST)

10.60 IU/L

0.99 (0.76, 1.29)

1.03 (0.92, 1.14)

1.02 (0.92, 1.13)

Alanine aminotransferase (ALT)

14.16 IU/L

0.69 (0.47, 1.04)

0.96 (0.75, 1.23)

0.88 (0.71, 1.08)

Alkaline phosphatase (ALP)

26.45 IU/L

0.99 (0.88, 1.12)

1.04 (0.96, 1.12)

1.02 (0.96, 1.09)

γ-glutamyl transferase (GGT)

42.18 IU/L

1.14 (0.95, 1.37)

1.08 (1.00, 1.16)

1.09 (1.01, 1.17)

Total protein (TP)

0.40 g/dL

1.07 (0.97, 1.18)

1.03 (0.94, 1.14)

1.05 (0.98, 1.13)

Serum albumin (Alb)

0.26 g/dL

1.19 (1.02, 1.39)

1.14 (0.99, 1.32)

1.17 (1.05, 1.29)

Renal function

Serum creatinine (sCr)

0.20 mg/dL

1.21 (1.07, 1.36)

0.93 (0.84, 1.02)

1.02 (0.95, 1.10)

Blood urea nitrogen (BUN)

3.90 mg/dL

1.13 (1.00, 1.28)

0.99 (0.88, 1.11)

1.06 (0.97, 1.15)

Uric acid (UA)

1.35 mg/dL

1.27 (1.13, 1.42)

1.02 (0.93, 1.11)

1.11 (1.03, 1.19)

Electrolyte

Calcium (Ca)

0.38 mg/dL

1.01 (0.89, 1.16)

0.98 (0.87, 1.11)

1.00 (0.91, 1.09)

Phosphorus (P)

0.50 mg/dL

0.91 (0.79, 1.05)

1.02 (0.90, 1.15)

0.97 (0.88, 1.07)

  1. a SD of each trait among white-British participants of UKB. OR of CAD was reported on the same SD unit of each quantitative trait for MR analyses in both Europeans and East Asians. b For T2D, OR of CAD was reported per unit change on the log odds scale