Table 2 Bi-directional UVMR analyses between RBC, Hb, Ht, UA and CAD

RBC

CAD

East Asian

136

11.24

1.21 (1.10, 1.33)

9.46×10⁻⁵

1.18 (1.07, 1.29)

1.02×10⁻³

1.20 (1.08, 1.33)

6.50×10⁻⁴

1.20 (1.09, 1.31)

1.44×10⁻⁴

European

139

50.64

1.06 (0.98, 1.16)

0.159

1.06 (0.96, 1.17)

0.274

1.06 (0.96, 1.18)

0.270

1.02 (0.94, 1.12)

0.592

Meta-analysis

-

-

1.12 (1.06, 1.20)

2.66×10⁻⁴

1.12 (1.04, 1.20)

1.67×10⁻³

1.13 (1.05, 1.21)

1.38×10⁻³

1.10 (1.03, 1.17)

2.87×10⁻³

Hb

CAD

East Asian

90

8.19

1.28 (1.11, 1.47)

4.87×10⁻⁴

1.21 (1.04, 1.40)

0.012

1.24 (1.05, 1.47)

0.013

1.25 (1.10, 1.42)

6.61×10⁻⁴

European

89

40.78

1.16 (1.03, 1.32)

0.018

1.16 (1.00, 1.34)

0.058

1.17 (1.00, 1.36)

0.050

1.15 (1.01, 1.31)

0.033

Meta-analysis

-

-

1.22 (1.11, 1.34)

4.29×10⁻⁵

1.18 (1.06, 1.31)

1.83×10⁻³

1.20 (1.07, 1.34)

1.80×10⁻³

1.20 (1.10, 1.31)

8.82×10⁻⁵

Ht

CAD

East Asian

105

8.66

1.31 (1.16, 1.48)

1.18×10⁻⁵

1.25 (1.09, 1.42)

9.62×10⁻⁴

1.30 (1.12, 1.50)

5.78×10⁻⁴

1.31 (1.16, 1.48)

1.20×10⁻⁵

European

106

41.67

1.22 (1.09, 1.38)

7.88×10⁻⁴

1.22 (1.06, 1.41)

7.01×10⁻³

1.23 (1.06, 1.43)

6.48×10⁻³

1.19 (1.06, 1.34)

2.71×10⁻³

Meta-analysis

-

-

1.27 (1.16, 1.38)

4.59×10⁻⁸

1.24 (1.12, 1.36)

2.07×10⁻⁵

1.26 (1.14, 1.40)

1.28×10⁻⁵

1.25 (1.15, 1.36)

2.14×10⁻⁷

UA

CAD

East Asian

57

26.02

1.27 (1.13, 1.42)

3.27×10⁻⁵

1.26 (1.11, 1.42)

1.81×10⁻⁴

1.26 (1.11, 1.43)

2.54×10⁻⁴

1.27 (1.13, 1.43)

3.77×10⁻⁵

European

56

105.3

1.02 (0.93, 1.11)

0.658

1.02 (0.92, 1.13)

0.723

1.01 (0.91, 1.13)

0.789

1.01 (0.92, 1.11)

0.881

Meta-analysis

-

-

1.11 (1.03, 1.19)

3.86×10⁻³

1.11 (1.03, 1.20)

6.61×10⁻³

1.11 (1.03, 1.21)

0.010

1.11 (1.03, 1.19)

6.49×10⁻³

CAD

RBC

East Asian

42

28.17

0.03 (0.00, 0.06)

0.099

0.02 (−0.01, 0.05)

0.108

0.03 (−0.01, 0.06)

0.110

0.03 (0.00, 0.05)

0.066

European

44

30.74

0.01 (0.00, 0.03)

0.179

0.01 (−0.01, 0.03)

0.330

0.01 (−0.01, 0.04)

0.270

0.01 (−0.01, 0.02)

0.339

Meta-analysis

-

-

0.01 (0.00, 0.03)

0.051

0.02 (0.00, 0.03)

0.081

0.02 (0.00, 0.04)

0.067

0.01 (0.00, 0.03)

0.079

CAD

Hb

East Asian

44

30.87

0.02 (0.00, 0.04)

0.075

0.02 (−0.01, 0.05)

0.124

0.02 (−0.01, 0.05)

0.120

0.02 (−0.01, 0.04)

0.119

European

43

29.82

0.02 (0.00, 0.04)

0.014

0.02 (0.00, 0.04)

0.089

0.02 (0.00, 0.04)

0.101

0.02 (0.01, 0.04)

4.30×10⁻³

Meta-analysis

-

-

0.02 (0.01, 0.03)

2.46×10⁻³

0.02 (0.00, 0.04)

0.022

0.02 (0.00, 0.04)

0.024

0.02 (0.01, 0.03)

1.15×10⁻³

CAD

Ht

East Asian

44

30.87

0.03 (0.00, 0.05)

0.061

0.03 (0.00, 0.05)

0.061

0.03 (0.00, 0.06)

0.055

0.02 (0.00, 0.05)

0.050

European

41

30.37

0.00 (−0.02, 0.02)

0.723

0.00 (−0.03, 0.02)

0.769

0.00 (−0.03, 0.02)

0.766

0.00 (−0.02, 0.01)

0.559

Meta-analysis

-

-

0.01 (−0.01, 0.02)

0.448

0.01 (−0.01, 0.03)

0.314

0.01 (−0.01, 0.03)

0.312

0.00 (−0.01, 0.02)

0.592

CAD

UA

East Asian

42

28.17

−0.01 (−0.03, 0.01)

0.431

−0.01 (−0.04, 0.02)

0.533

−0.01 (−0.04, 0.02)

0.585

0.00 (−0.03, 0.03)

0.914

European

46

30.48

0.00 (−0.01, 0.02)

0.620

0.00 (−0.02, 0.02)

0.737

0.01 (−0.01, 0.02)

0.600

0.01 (−0.01, 0.02)

0.406

Meta-analysis

-

-

0.00 (−0.01, 0.01)

0.972

0.00 (−0.02, 0.01)

0.944

0.00 (−0.01, 0.02)

0.888

0.00 (−0.01, 0.02)

0.507