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Table 2 Bi-directional UVMR analyses between RBC, Hb, Ht, UA and CAD

From: Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

Exposure Outcome Population IVs F MR-Corr IVW BWMR RAPS
Effect sizea P Effect sizea P Effect sizea P Effect sizea P
RBC CAD East Asian 136 11.24 1.21 (1.10, 1.33) 9.46×10−5 1.18 (1.07, 1.29) 1.02×10−3 1.20 (1.08, 1.33) 6.50×10−4 1.20 (1.09, 1.31) 1.44×10−4
European 139 50.64 1.06 (0.98, 1.16) 0.159 1.06 (0.96, 1.17) 0.274 1.06 (0.96, 1.18) 0.270 1.02 (0.94, 1.12) 0.592
Meta-analysis - - 1.12 (1.06, 1.20) 2.66×10−4 1.12 (1.04, 1.20) 1.67×10−3 1.13 (1.05, 1.21) 1.38×10−3 1.10 (1.03, 1.17) 2.87×10−3
Hb CAD East Asian 90 8.19 1.28 (1.11, 1.47) 4.87×10−4 1.21 (1.04, 1.40) 0.012 1.24 (1.05, 1.47) 0.013 1.25 (1.10, 1.42) 6.61×10−4
European 89 40.78 1.16 (1.03, 1.32) 0.018 1.16 (1.00, 1.34) 0.058 1.17 (1.00, 1.36) 0.050 1.15 (1.01, 1.31) 0.033
Meta-analysis - - 1.22 (1.11, 1.34) 4.29×10−5 1.18 (1.06, 1.31) 1.83×10−3 1.20 (1.07, 1.34) 1.80×10−3 1.20 (1.10, 1.31) 8.82×10−5
Ht CAD East Asian 105 8.66 1.31 (1.16, 1.48) 1.18×10−5 1.25 (1.09, 1.42) 9.62×10−4 1.30 (1.12, 1.50) 5.78×10−4 1.31 (1.16, 1.48) 1.20×10−5
European 106 41.67 1.22 (1.09, 1.38) 7.88×10−4 1.22 (1.06, 1.41) 7.01×10−3 1.23 (1.06, 1.43) 6.48×10−3 1.19 (1.06, 1.34) 2.71×10−3
Meta-analysis - - 1.27 (1.16, 1.38) 4.59×10−8 1.24 (1.12, 1.36) 2.07×10−5 1.26 (1.14, 1.40) 1.28×10−5 1.25 (1.15, 1.36) 2.14×10−7
UA CAD East Asian 57 26.02 1.27 (1.13, 1.42) 3.27×10−5 1.26 (1.11, 1.42) 1.81×10−4 1.26 (1.11, 1.43) 2.54×10−4 1.27 (1.13, 1.43) 3.77×10−5
European 56 105.3 1.02 (0.93, 1.11) 0.658 1.02 (0.92, 1.13) 0.723 1.01 (0.91, 1.13) 0.789 1.01 (0.92, 1.11) 0.881
Meta-analysis - - 1.11 (1.03, 1.19) 3.86×10−3 1.11 (1.03, 1.20) 6.61×10−3 1.11 (1.03, 1.21) 0.010 1.11 (1.03, 1.19) 6.49×10−3
CAD RBC East Asian 42 28.17 0.03 (0.00, 0.06) 0.099 0.02 (−0.01, 0.05) 0.108 0.03 (−0.01, 0.06) 0.110 0.03 (0.00, 0.05) 0.066
European 44 30.74 0.01 (0.00, 0.03) 0.179 0.01 (−0.01, 0.03) 0.330 0.01 (−0.01, 0.04) 0.270 0.01 (−0.01, 0.02) 0.339
Meta-analysis - - 0.01 (0.00, 0.03) 0.051 0.02 (0.00, 0.03) 0.081 0.02 (0.00, 0.04) 0.067 0.01 (0.00, 0.03) 0.079
CAD Hb East Asian 44 30.87 0.02 (0.00, 0.04) 0.075 0.02 (−0.01, 0.05) 0.124 0.02 (−0.01, 0.05) 0.120 0.02 (−0.01, 0.04) 0.119
European 43 29.82 0.02 (0.00, 0.04) 0.014 0.02 (0.00, 0.04) 0.089 0.02 (0.00, 0.04) 0.101 0.02 (0.01, 0.04) 4.30×10−3
Meta-analysis - - 0.02 (0.01, 0.03) 2.46×10−3 0.02 (0.00, 0.04) 0.022 0.02 (0.00, 0.04) 0.024 0.02 (0.01, 0.03) 1.15×10−3
CAD Ht East Asian 44 30.87 0.03 (0.00, 0.05) 0.061 0.03 (0.00, 0.05) 0.061 0.03 (0.00, 0.06) 0.055 0.02 (0.00, 0.05) 0.050
European 41 30.37 0.00 (−0.02, 0.02) 0.723 0.00 (−0.03, 0.02) 0.769 0.00 (−0.03, 0.02) 0.766 0.00 (−0.02, 0.01) 0.559
Meta-analysis - - 0.01 (−0.01, 0.02) 0.448 0.01 (−0.01, 0.03) 0.314 0.01 (−0.01, 0.03) 0.312 0.00 (−0.01, 0.02) 0.592
CAD UA East Asian 42 28.17 −0.01 (−0.03, 0.01) 0.431 −0.01 (−0.04, 0.02) 0.533 −0.01 (−0.04, 0.02) 0.585 0.00 (−0.03, 0.03) 0.914
European 46 30.48 0.00 (−0.01, 0.02) 0.620 0.00 (−0.02, 0.02) 0.737 0.01 (−0.01, 0.02) 0.600 0.01 (−0.01, 0.02) 0.406
Meta-analysis - - 0.00 (−0.01, 0.01) 0.972 0.00 (−0.02, 0.01) 0.944 0.00 (−0.01, 0.02) 0.888 0.00 (−0.01, 0.02) 0.507
  1. a Effect size corresponds to OR if the outcome is CAD or β if the outcome is RBC, Hb, Ht, or UA. 95% CI is indicated in the parentheses
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