Fig. 6

Interactions between genetic alterations. A Volcano plot with dots representing pairs of two separate genetic alterations. The log₂ ratio of the observed and expected co-occurrence frequency is plotted on the x-axis against the −log₁₀ (FDR) on the y-axis. Pairs with FDR (corrected p-value from Fisher’s exact test) < 0.05 are colored in red. B Circos plots showing clusters of translocations (gray lines) joining regions on chromosome 6q12 and 11q13-14 in 7 samples. The outer track shows the chromosome ideograms; the middle track shows the log₂ ratio of tumor to normal copy number (purple dots) with the dashed black line indicating 0