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Fig. 4 | Genome Medicine

Fig. 4

From: Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes

Fig. 4

Age-dependent penetrance for carriers and non-carriers of a SORL1 LoF variant. The penetrance is displayed with its 95% confidence interval according to the number of APOE-ε4 allele from 65 to 85 years of age. Curves for non-carriers and their confidence intervals were obtained from our estimation of λnc(t | a) based on the Rotterdam Study. Data from pedigrees were censored at 85 years. Confidence intervals for SORL1-LoF variant carriers were obtained from the 2.5th and 97.5th quantiles of 500 bootstrap iterations. Penetrance values at 65, 70, 75, 80, and 85 years of age for carriers of the SORL1-LoF variant are displayed below the figure

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