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Fig. 2 | Genome Medicine

Fig. 2

From: Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

Fig. 2

Comparison of the predictive performance of PRS-CSx with three alternative PRS construction methods in the African and Hispanic/Latino samples of the eMERGE dataset. Alternative PRS methods include (i) a European-specific score derived by applying PRS-CS-auto to the European T2D GWAS summary statistics (PRS-CS EUR); (ii) a trans-ancestry score derived by applying PRS-CS-auto to the meta-analysis of the European, MEDIA and BBJ T2D GWAS (PRS-CS Meta); and (iii) a trans-ancestry score derived by applying LDpred2-auto to the T2D meta-GWAS (LDpred2 Meta)

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Genome Medicine

ISSN: 1756-994X

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