Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

Table 2 Prediction accuracy of the trans-ancestry T2D PRS in eMERGE across three populations

Population	Liability R²	Covariates-adjusted AUC	OR per SD (95% CI)	Top 2% PRS
Population	Liability R²	Covariates-adjusted AUC	OR per SD (95% CI)	OR (95% CI)	P value	Sensitivity	Specificity	Adjusted PPV*	Adjusted NPV*
European	9.2%	0.66	1.96 (1.91, 2.02)	4.21 (3.66, 4.84)	1.82E−89	0.05	0.99	0.26	0.90
African	2.8%	0.58	1.54 (1.46, 1.64)	1.98 (1.43, 2.74)	4.34E−05	0.03	0.98	0.21	0.88
Hispanic	8.0%	0.63	2.08 (1.84, 2.35)	6.87 (3.11, 15.15)	1.81E−06	0.04	0.99	0.43	0.87

*Adjusted PPV and NPV are calculated using the following population-specific prevalence: European 10%; African 12.5%; Hispanic 13.1%

ISSN: 1756-994X