Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

Table 4 Prediction accuracy of the trans-ancestry T2D PRS in the Taiwan Biobank (TWB)

Batch	Liability R²	Covariates-adjusted AUC	OR per SD (95% CI)	Top 2% PRS
Batch	Liability R²	Covariates-adjusted AUC	OR per SD (95% CI)	OR (95% CI)	P value	Sensitivity	Specificity	Adjusted PPV*	Adjusted NPV*
Batch 1	15.1%	0.70	2.19 (2.05, 2.33)	4.62 (3.56, 5.99)	7.47E−31	0.07	0.98	0.37	0.87
Batch 2	12.9%	0.68	2.01 (1.93, 2.10)	4.60 (3.88, 5.45)	1.80E−69	0.07	0.98	0.38	0.87
Batch 3	15.3%	0.70	2.16 (1.96, 2.38)	4.35 (2.89, 6.53)	1.43E−12	0.06	0.98	0.36	0.87

ISSN: 1756-994X