Fig. 6From: Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiersDNA methylation levels in FASN have predictive value for insulin resistance. a Epigenetic association from regression between VF and FASN DNA methylation (N = 538) displayed in a coMET plot [80], including VF-methylation association profiles (top panel) along with functional annotation of the region (middle panel), and pattern of co-methylation at the 53 CpG sites in the 450k array annotated to FASN (bottom panel). Broad ChromHMM regions are displayed using UCSC genome browser colour schemes. b ROC curves for insulin resistance based on unadjusted (not normalised) DNA methylation levels at cg11950105 (FASN) and age, smoking, BMI, SAT cell composition and technical covariates (n = 397, 114 cases/284 controls)Back to article page