Fig. 6

Association of EIC with somatic mutations, neoantigens, and copy number alteration. A, D The landscape of most frequently mutated genes between the EIC and the rest class in late-stage and early-stage LUSC, respectively. B, E Box plots show the number of mutations between two classes in late-stage and early-stage LUSC, respectively. C, F Box plots show the number of neoantigens between two classes in late-stage and early-stage LUSC, respectively. G Pearson correlation analysis between scaled the EIC score and the number of mutations across LUSC cohorts of late-stage, early-stage, and all-stage, respectively. H, L Box plots show significant difference of amplification burden of cytoband between two classes in late-stage and early-stage LUSC, respectively. I, M Box plots show significant difference of deletion burden of cytoband between two classes in late-stage and early-stage LUSC, respectively. For late-stage (J) and early-stage (N) LUSC, the frequency of patients with amplification of driver genes in two classes. For late-stage (K) and early-stage (O) LUSC, the frequency of patients with deletion of driver genes in two classes. All statistical significances of two classes were computed by Wilcoxon rank-sum test; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001