Fig. 2

Association of copy number alteration with clinical outcome measures. A–D Cox survival model demonstrating adjusted estimate of impact of burden of copy number (CN) alteration as a continuous variable on hazard of A failure-free survival; B metastatic progression-free survival; C prostate cancer-specific survival; D overall survival. Variables included in adjusted analysis: (1) grading group; (2) metastatic state (M0N0, M0N1, M1 low and M1 high); (3) Pre-ADT serum PSA log transformed; (4) age at randomisation; (5) tumour cellularity (%). Black line represents the impact of the burden of copy number alteration on relative risk for 284/300 patients for which we could determine disease state (16 M1 patients with unknown designation for low versus high volume were excluded). Each coloured line represents sub-groups of the CN-300 cohort defined by metastatic state. E–H Kaplan-Meier estimates. CN-300 cohort split into quartile groups determined by the burden of copy number alteration. Time-to event; E failure-free survival; F metastatic progression-free survival; G prostate cancer-specific survival; H overall survival