Fig. 3

Proportion of copy number alteration attributable to loss as compared to gain. A–D Patients are ranked with ascending burden of copy number (CN) alteration (%) identified in the index core on the x-axis. Y-axis represents the proportion of copy number alteration (%) attributable to a gain (red dot) as compared to a loss (blue dot). The line represents the conditional mean (blue=loss, red=gain), i.e. an estimate of the mean proportions conditional on the number of patients (LOESS function). The grey band indicates the confidence interval (level of confidence 0.95) A M0N0 patients; B M0N1 patients; C M1 low patients; D M1 high patients. E Density plot representing the proportion of the genome altered by a copy number loss in the index core. Each line sub-groups the CN-300 cohort into burden of copy number alteration quartiles. F Boxplot demonstrating the difference in ratio of the burden of copy number alteration due to a gain as compared to a loss (log transformed) between non-metastatic (M0) and metastatic (M1) patients