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Fig. 5 | Genome Medicine

Fig. 5

From: Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Fig. 5

Variance in copy number alteration across multi-region diagnostic cores. A For a sub-set of 112 patients within the CN-300 cohort, we were able to copy number profile multiple diagnostic core biopsies from the same prostate (N=500, median 4 diagnostic core biopsies per patient). We calculated the variance in burden of copy number alteration (%) defined as the standard deviation across cores from the same prostate, represented as a dot. The colour and size of the dot represents the number of diagnostic cores copy number profiled per patient (grey=2, brown=>2) ranked in ascending order of burden of copy number alteration identified in the index core. Metastatic status of each patient is annotated (green=non-metastatic, blue=metastatic). Burden of copy number alteration (PGA=percentage genome altered) is represented as a bar with each patient split by proportion of gain (red) and loss (blue). Bottom bar chart represents number of diagnostic cores sequenced per patient. B Distribution of variance (%) of burden of copy number alteration per patient compared between non-metastatic (green violin plot) and metastatic (blue violin plot). Dot size represents number of cores sequenced per patient. C Boxplot demonstrating intra-patient heterogeneity of selected regions of interest. Regions annotated on x-axis labelled with chromosome number and genomic location mapped to cytoband. Blue=segment loss, red=segment gain. Within each bar, patients are only included if we sequenced more than one core and they harbour at least one core with the annotated alteration (numbers of patients annotated beneath x-axis). Y-axis represents the percentage of cores within patients harbouring the alteration and the boxplot line represents the median across patients

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