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Fig. 8 | Genome Medicine

Fig. 8

From: Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis

Fig. 8

Shared Gene Regulatory Networks in SFs of hTNFtg mice and human RA. A Regulatory network analysis in mouse and human datasets reveals 17 shared regulons. Correlation and clustering analysis in the hTNFtg propose organization of those shared regulons in 3 main modules. B The activity of regulons AR, RUNX1, and DLX3 is depicted in a UMAP of the human data. C Summary table for the GO enrichment analysis in the target genes of the modules shown in A. For each module, the TFs can be found in the second column. In the third column, commonly enriched GOs for mouse and human regulons in each module are presented followed by their respective p-values

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