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Fig. 1 | Genome Medicine

Fig. 1

From: Whole genome sequencing reveals the independent clonal origin of multifocal ileal neuroendocrine tumors

Fig. 1

Mutational analysis of 75 synchronous primary ileal NETs and 15 metastases. Top panel, somatic mutation rate per Mb for all 90 tumors. Tumor sites are indicated by colored boxes. P, primary tumor; M, metastasis. Second panel, the most recurrent somatic copy-number alterations (CNAs) identified in both primary ileal NETs and metastases that are present in at least two ileal NET patients. The CNAs are arranged by chromosome number order. Focal CNAs are marked with “F” to differentiate them from whole chromosome and whole chromosome arm events. Third panel, the ten most frequently mutated genes in primary ileal NETs and metastases present in two or more ileal NET patients. Fourth panel, the most recurrent somatic noncoding variants identified in primary ileal NETs and metastases that are present in more than one ileal NET patient. Bottom panel, all recurrent structural variants (SVs) that are present in at least two ileal NET patients. The SVs are arranged by chromosome number order. Chromosome number of the second breakpoint of the interchromosomal rearrangement has been marked in the colored box

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