Skip to main content
Fig. 3 | Genome Medicine

Fig. 3

From: A genetic model for central chondrosarcoma evolution correlates with patient outcome

Fig. 3

Outcomes in chondrosarcoma. A Tumour size of IDH1, IDH2, and IDHwt CS are different at presentation and their anatomical location are largely comparable, although IDHwt tumours develop more frequently in the chest wall and spine (left and middle, and right, respectively). B Kaplan-Meier analysis and hazard ratios (HR) from Cox proportional hazard analysis confirms tumour grade, and anatomical location, as predictors of outcome. The frequency of metastatic/recurrent disease is significantly lower in IDH2 G2/3 disease compared to IDH1 G2/3 disease but is comparable in DD CS. The time interval between diagnosis and discovery of metastatic disease is shortest in IDH2-driven tumours and on average longest in IDHwt (while also being less frequent). Median time in days given right of plot. C TERT mutations are linked to poor outcome, as is methylation of TERT (left plots). In high-grade (G2/3 and DD CS) IDH1 tumours, TERT mutations associate with a poor outcome, but not in IDH2 tumours

Back to article page