Fig. 5
From: Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Changes in allele fractions of key drivers during treatment. a Parallel coordinate plots showing the relative variant allele frequency (rVAF; corrected for tumor cell fraction) for mutations in key breast cancer genes, across sequential epirubicin and docetaxel* for individual patients harboring mutations in these genes. Lines are colored based on the response to each of the two treatments. Asterisk: hormone receptor positive, HER2 normal (HR+HER2−) tumors; triangle: HER2+ tumors; squares: triple-negative breast cancers (TNBC). b Plots for alterations in signaling pathways/biological processes. The Y-axis indicates rVAF for mutations affecting genes involved in the illustrated pathways, while the X-axis indicates the three time points (pretreatment, post-epirubicin, and post-docetaxel). Lines are colored based on the response of each of the two treatments. Asterisk: HR+HER2− tumors, triangle: HER2+ tumors, squares: TNBC. *HER2-positive breast cancers received concomitant docetaxel and trastuzumab