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Fig. 4 | Genome Medicine

Fig. 4

From: Improved SARS-CoV-2 sequencing surveillance allows the identification of new variants and signatures in infected patients

Fig. 4

Transcriptional profiling of SARS-CoV-2 infected patients reveals a gene signature correlated with viral load and preserved across different lineages. A Correlation analysis between CTs and gene expression of B.1 patients, performed on 8100 genes, is shown as a barplot. For each gene (x-axis), its correlation value (y-axis) and significance (p-value < 0.0001, red) is reported. Bottom: highlight of the significant results. (161 genes). The top 10 most anti-correlated genes are reported (black box). B Pathway and gene set enrichment analysis performed for different databases using the gene signature previously identified. Each barplot shows the significance (x-axis) and the percentage of overlap (fill color) between the input signature and the tested public genesets. C Heatmap of z-scored, log2-transformed, and normalized gene counts for the 161 significantly correlated genes from A. Values have been averaged in 4 groups of samples depending on the CT (x-axis) or whether they were negative. D Venn diagram of significantly anti-correlated genes between B.1 (161 genes) and Delta (16 genes) variant-infected patients

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