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Fig. 3 | Genome Medicine

Fig. 3

From: Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome

Fig. 3

Disruption of the biogeographic relationship between the cecal and sigmoid MLI microbiome in quiescent CD. A The per-subject differences in alpha diversity (Chao1, Shannon) between cecum and sigmoid MLI samples are shown for CD and controls divided by BMI category. Significance of differences between CD and non-IBD was determined by the Wilcoxon rank-sum test. **p<0.01. B PCoA plots of Bray-Curtis dissimilarity for CD and controls depicting each subject as a line with the ends colored by site (cecum vs. sigmoid). C Bray-Curtis dissimilarity between paired cecum and sigmoid MLI samples are shown for CD and controls divided by BMI category. **p<0.01 Wilcoxon rank-sum test. D ASVs with a statistically significant difference in relative abundance between cecum and sigmoid in DESeq2 models adjusted for subject are shown for CD and controls

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