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Fig. 5 | Genome Medicine

Fig. 5

From: Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome

Fig. 5

Stricturing/penetrating CD is associated with lower diversity and taxonomic shifts in the MLI microbiome. A Alpha diversity metrics (Chao1, Shannon) are shown for the cecal and sigmoid colon MLI microbiome of CD patients stratified by uncomplicated (B1) or complicated (B2/B3) disease behavior according to the Montreal classification. Significance was determined by ANOVA adjusting for gender, age, and obesity. *p<0.05, **p<0.01. B PCoA plots based on Bray-Curtis dissimilarity showing the cecal and sigmoid microbiome of CD patients, colored by disease behavior. p-values calculated by multivariate PERMANOVA adjusting for gender, age, and obesity. C ROC curves for random forest classifiers differentiating CD patients with complicated CD compared to those with uncomplicated CD using MLI bacterial profiles in the sigmoid or cecum. D CD dysbiosis index is shown for non-IBD controls and CD patients stratified into B1 and B2/B3. *p<0.05, **p<0.01, ***p<0.001. E ASVs in the cecal and sigmoid MLI microbiome that were differentially abundant between complicated and uncomplicated CD controlling for gender and obesity

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Genome Medicine

ISSN: 1756-994X

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