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Fig. 6 | Genome Medicine

Fig. 6

From: Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome

Fig. 6

MLI microbiome is associated with risk of Crohn’s disease progression. A ASVs in the cecal and sigmoid MLI microbiome significantly associated with disease progression over a mean follow-up period of 3.7 years after adjusting for gender, obesity, and CD disease behavior. B ROC curves for random forest classifiers predicting future disease progression from MLI bacterial profiles in the sigmoid or cecum. C Importance scores of ASVs included in the sigmoid and cecal random forest classifiers for disease progression. Bar color represents phylum and the color of the genus annotations to the left indicates whether the ASVs were enriched or depleted in CD progressors

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