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Fig. 3 | Genome Medicine

Fig. 3

From: ESBL plasmids in Klebsiella pneumoniae: diversity, transmission and contribution to infection burden in the hospital setting

Fig. 3

ESBL plasmid cluster network for all completed KpSC ESBL + genomes. a blaCTX-M-15 plasmids; b blaCTX-M-14 plasmids; c other detected ESBLs. Each node represents a completed genome (from one representative isolate per patient), coloured by the bacterial host cell ST as per legend. Dashed outline surrounding dot indicates if the ESBL is carried on both a plasmid and the chromosome. Nodes are connected if they share a similar plasmid sequence, defined as mash similarity ≥ 0.98 and gene content similarity ≥ 0.8 (see Additional file 2: Fig. S1); line colour and width indicate plasmid gene content similarity (as per legend). Clusters comprising ≥ 2 genomes are labelled with the median jaccard gene similarity score. ‘ + blaOXA-48 (Plasmid M)’ and ‘ + blaIMP-4 (Plasmid N)’ indicate STs that carry an additional carbapenemase plasmid (details in Additional file 4: Table S3)

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