Fig. 4

Timeline of ESBL + infection and carriage episodes. a ESBL + Klebsiella infection episodes (all wards) and carriage episodes from the ICU. Each episode is represented by a single isolate, grouped in rows by the isolate ST. Colours indicate the ESBL enzyme encoded in the genome (as per legend), and shapes indicate whether the episode was carriage (circle) or infection (triangle). Presence of the ESBL plasmid most commonly associated with the ST is indicated by filled shapes (with plasmid name listed under ST on the y-axis). ESBL genes on the chromosome rather than plasmid are indicated by shapes with no fill and a coloured outline. Kp, K. pneumoniae; Kv, K. variicola. b ESBL + Escherichia infection (ICU-only) and carriage episodes from the ICU. Each episode is represented by a single isolate, shapes and colours as per panel a. Grey box indicates that no data was available for this period for the Escherichia STs. Ec, E. coli; Em, E. marmotae