Fig. 4

Comparison of the mutational landscape between HLBC-FPO and MSKCC control cohorts. Spider plots depicting multiple comparisons. On the y-axis of the spider plot, we report the number of genes with a significantly different number of mutations (multiple Fisher’s exact test with FDR adjustment) between the reference group and each control group, for both P-value (red) and adjusted P-value (blue). A Spider plot comparing the HLBC-FPO group and the MSKCC BC (unmatched and matched) control cohorts. For instance, when considering the whole HLBC-FPO cohort, we detected 19 differentially mutated genes with respect to the HER2-negative unmatched cohort and 16 for the HER2-negative matched cohort. The same comparisons run after FDR adjustment resulted in 9 and 8 differentially mutated genes. When the whole HLBC-FPO cohort was compared with HER2-positive tumors, we detected 11 differentially mutated genes with respect to the unmatched cohort and 4 for the matched cohort. The same comparisons run after FDR adjustment resulted in 4 differentially mutated genes for both. B Spider plot comparing the HLBC-1 group, the HLBCs-2E and 2N, and the MSKCC BC (unmatched and matched) control cohorts. C Spider plot comparing the HLBC-2N group, the HLBCs-1 and 2E, and the MSKCC BC (unmatched and matched) control cohorts. D Spider plot comparing the HLBC-2E group, the HLBCs-1 and 2N, and the MSKCC BC (unmatched and matched) control cohorts