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Table 2 Multivariate Cox analyses of cancer-specific survival in 237 patients of the validation cohort (C5) with \({P}_{psa}<0.05\) and all clinicopathological parameters available

From: A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy

Variable

Level

Hazard ratio (95% CI)

P-value

Sex

 

Female

1

 

Male

0.88 (0.46–1.70)

0.71

Age, years

 

Linear

0.99 (0.97–1.02)

0.59

T

 

1

1

 

2

1.83 (0.4–8.43)

0.44

3

5.12 (2.1–12.51)

3.4E − 04

4

11.49 (2.54–51.88)

1.5E − 03

N

 

0

1

 

1/2

1.62 (0.73–3.62)

0.24

X

0.53 (0.14–1.96)

0.34

M

 

0

1

 

1

6.06 (2.74–13.41)

8.7E − 06

X

1.45 (0.32–6.51)

0.63

Tumor size, cm

 

Linear

0.92 (0.83–1.02)

9.7E − 02

Histology

 

ccRCC

1

 

pRCC

2 (0.96–4.16)

6.2E − 02

chRCC

8.8 (0.86–89.78)

6.7E − 02

Mixed

1.88 (0.28–12.67)

0.52

PI5 (RCC-R score)

 

Linear

2.14 (1.14–4.04)

1.8E − 02