Fig. 2
From: Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
Cell type-specific responses of kidney cells to acute injury. A Absolute numbers of differentially expressed (DE) genes upregulated and downregulated in AKI versus controls within major kidney cell types. B Dot plot displaying the degree of differential expression for known injury marker genes and housekeeping control genes (actin beta (ACTB), ataxin 2 (ATXN2), and RNA polymerase III subunit A (POLR3A)). C, D Dot plots for top enriched pathways (defined by FDR) in genes upregulated (C) and downregulated (D) in AKI versus controls. Note that although the number of DE genes varied strongly between the cell types (e.g., Podo vs. PT), we observed similar enrichment results in several cell types. HM – Molecular Signatures Database (MSigDB) hallmark gene sets, MSigDB canonical pathway gene sets derived from RC, Reactome; WP, WikiPathways; and KEGG, Kyoto Encyclopedia of Genes and Genomes