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Fig. 1 | Genome Medicine

Fig. 1

From: Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis

Fig. 1

Defining the core and function-specific MES programs. A Heatmap shows 10 GBM MES signatures clustered by their similarity as defined by Jaccard Index. Annotation bar shows the human or mouse origin of each signature. Signature names include the first author of the associated study; Gangoso_MES_IE represents the immune evasion signature from Gangoso et al.; Hara_OSM represents the signature of upregulated genes after GBM cells were treated with OSM in Hara et al. Left: scheme explaining how the MES functional programs and core MES signatures were defined. Right: gene lists of all novel MES signatures (see full list in Additional file 1: Table S3). C Heatmap depicting the percentage of genes from each core or function-specific MES signature (Y-axis) that are included in each of the published MES signatures (X-axis). Published signatures are ordered by the percentage of genes from the core MES program. D Distributions of the core MES scores (pink) of cells from IDH-WT GBM (left), IDH-mutant glioma (top right), and H3-K27M glioma (bottom right). The light color represents core MES scores of the shuffled dataset. A threshold of 1 and the percentage of cells that pass it are also included in each panel

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