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Fig. 3 | Genome Medicine

Fig. 3

From: Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis

Fig. 3

MES association with macrophage states. A Scatterplot showing the correlations of 340 macrophage-specific genes (dots) with estimated macrophage abundance (X-axis), as defined by average expression of canonical macrophage markers (CD14, AIF1, CD163, TYROBP, CSF1R) and with core MES scores (Y-axis), across TCGA bulk RNA-seq samples. Line indicates a LOESS regression and a confidence interval is shown in grey. Dot colors indicate marker genes for macrophage subtypes (microglia, macrophage, M1 activation, M2 activation). Bā€“D Bars show correlations or partial correlations of the core MES scores with macrophage-related scores: macrophage abundance as defined above (B), the difference between macrophage and microglia scores (C) or the difference between M2 and M1 scores (D). Partial correlations are included to control for MES-Hyp (yellow) or MES-Ast (brown) scores. Error bars correspond to Q1 and Q3, calculated by bootstrapping 75 tumors with 1000 iterations; the difference between averages is significant by Wilcoxon rank sum test (**** p< 2.2eāˆ’16)

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