Fig. 6
From: Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma
Spatial patterns of malignant B cell clusters reflect their transcriptional heterogeneity across patients. A–D Spatial feature plots of the integrated malignant B cell clusters of patients 1 (A), 2 (B), 3 (C), and 7 (D). The transcriptional expression is overlaid on top of the tissue histology. The gene expression of the integrated clusters is encoded by color and transparency. E–H Spatial feature plots of canonical T cell exhaustion markers of patients 1 (E), 2 (F), 3 (G), and 7 (H). The gene expression is encoded by color and transparency. Gene name - alias: HAVCR2 - TIM3; PDCD1 - PD1. Abbreviations: mBc - malignant B cells; nm - non-malignant B cells