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Fig. 4 | Genome Medicine

Fig. 4

From: Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination

Fig. 4

Cxcr6 −/− animals have decreased maintenance of CD8+ T cells in the post-infectious CNS. a Representative gating strategy and quantification of the percentage of CD8+ T cells within the cortex and hippocampus at 7, 25, and 52 DPI (left graph), followed by total CD8+ cell numbers at 52 DPI in WT versus Cxcr6 −/− mice (right graph). b Representative gating strategy and quantification of the percentage of CD103+ cells within the cortex and hippocampus at 7, 25, and 52 DPI, followed by total CD103+ cell numbers at 52 DPI, in WT versus Cxcr6 −/− mice. c Representative gating strategy and quantification of the percentage of NS4B+ cells within the cortex and hippocampus at 7, 25, and 52 DPI, followed by total NS4B+ cell numbers at 52 DPI in WT versus Cxcr6 −/− mice. Cells were gated according to the gating strategy in Additional file 1: Fig. S8. Data represent the mean±s.e.m. and were analyzed by unpaired Student’s t-test at 7, 25, and 52 DPI. *P<0.05, **P<0.005

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