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Fig. 7 | Genome Medicine

Fig. 7

From: Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination

Fig. 7

CXCL16 neutralization leads to decreased percentage of TRM cells in the CNS after viral clearance. a. Schematic depicting experimental design for CXCL16 neutralizing an-tibody experiment. Mice were infected (i.c.) with 1×104 p.f.u. WNV-NS5-E218A and administered CXCL16 antibody or isotype control via retro-orbital injection, and harvested 15 DPI. b. Quantifi-cation of percentage of CD45high cells that are CD8+ in the cortex (left) and hippocampus (right) in mice that received isotype or CXCL16 neutralizing antibody. c. Gating strategy and quantifi-cation of percentage of CD8+ T cells that are CD103+ in the cortex and hippocampus in mice that received isotype or CXCL16 neutralizing antibody. Data represent the mean±s.e.m. and were analyzed by unpaired Student’s t-test. *P<0.05

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