Fig. 1

Common haplotypes at the 17q12-q21 locus. A Ten genes and their relative locations at the extended locus (chr17:37815888-38143768; build hg19). Genes at the core, proximal, and distal regions are color coded (modified from Stein et al. [11] and Ober et al. [17]). The five variants defining the core region haplotypes and their locations relative to each gene are shown. B Results of logistic regression analysis for haplotypes with frequencies ≥0.05; haplotype 1 is the reference haplotype. C Allelic composition of the five variants on four haplotypes. Yellow background corresponds to alleles on the non-risk haplotype (haplotype 1) and red background corresponds to alleles on the risk haplotype (haplotype 2 in European-ancestry populations). The purple star denotes the high-risk haplotype in African Americans. D Haplotype frequencies