Fig. 4

pcHi-C loops and ATAC-seq peaks at 17q12-q21 locus from IKZF3 to GSDMA. The region harboring the 9 novel variants is shown in yellow and the location of the variants are show as vertical lines under the genes. The two candidate variants are indicated by an orange arrow. H3K27ac marks in NHEK (skin) cells from ENCODE are shown as blue tracks (also see Fig. 3B and Additional file 1: Fig. S11). ATAC-seq tracks of open chromatin for two airway epithelial cell lines (16HBE and SAEC) are shown in green. All pcHi-C interactions within this view in airway epithelial cells are shown. Two interactions between GSDMA with three of the nine variants (±1kb) were observed (shown as red loops). Two of those variants (orange arrow) were also eQTLs for GSDMA. All genes showing pcHi-C interactions with the 9 variants (±1kb) are shown in Additional file 1: Table S7