African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans

Table 3 cis-eQTL mapping results for the nine novel variants

SNP-effect allele	Position (hg38)	Gene	t-statistic	Beta	P-value	FDR
rs150276395-G	chr17:39908449	GSDMA	2.59	0.66	0.0100	0.320
rs8065520-T	chr17:39915395	GSDMA	3.40	0.72	0.00084	0.056
rs73985226-A	chr17:39920081	GSDMA	3.22	0.83	0.0016	0.079
rs73985227-A	chr17:39921437	GSDMA	3.51	0.89	0.00059	0.055
rs28623237-C	chr17:39924694	GSDMA	3.45	0.74	0.00072	0.056
rs73985229-A	chr17:39925400	GSDMA	3.35	0.86	0.0010	0.057
rs113282230-T	chr17:39927157	GSDMA	3.35	0.86	0.0010	0.057
rs113571956-T	chr17:39927234	GSDMA	3.35	0.86	0.0010	0.057
rs73985230-C	chr17:39929476	GSDMA	3.06	0.79	0.0026	0.110

Each variant was tested for association with expression of all genes whose transcription start site is ±500 kb away and detected as expressed in airway epithelial cells from 189 African American children in the URECA cohort
Results with uncorrected p-values <0.05 are shown. All results are shown in Additional file 2. The t-statistic from Matrix eQTL is shown

ISSN: 1756-994X