Fig. 2
From: Transcriptional signatures of the BCL2 family for individualized acute myeloid leukaemia treatment
Identification of BCL2 family-based acute myeloid leukaemia (AML) subtypes. A Profiles of BCL2 family signatures calculated using optimized genes in each RNA-seq dataset (BeatAML, LeuceGene, and TCGA). These datasets show three distinct clusters annotated as BCL2, MCL1/BCL2, and BFL1/MCL1 signature subtypes. Columns are clustered using hierarchical clustering with average distance. B Sample proportion of these subtypes. C Comparison of BCL2 family signatures between venetoclax response groups in BeatAML (81 sensitive and 72 resistant) and LeuceGene (20 sensitive and 3 resistant). P-values are calculated by Welch’s t-test. * < 0.05, ** < 0.01, ns > 0.10. D A profile of BCL2 family signatures in the NanoString dataset. The samples are also divided into three clusters resulting from RNA-seq datasets