The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

Table 1 Experimental design. Pathological diagnosis included cervical intraepithelial neoplasia (CIN), invasive cancer, and adenocarcinoma in situ (AIS)

Set	Type	Cytology-pos	Cytology-neg
Discovery set^a
n		170	202
Mean age (range)		32.5 (23–62)	34.7 (23–60)
Pathological diagnosis	Invasive cancer	6 (3%)	-
	AIS	7 (4%)	-
	CIN3	157 (93%)	-
Diagnostic validation set^b
n		343	111
Mean age (range)		33.1 (23–53)	35.2 (23–60)
Pathological diagnosis	Invasive cancer	3 (1%)	-
	CIN3	84 (25%)	-
	CIN2	90 (26%)	-
	CIN1	166 (48%)	-
Predictive validation set
n		210	218
Mean age (range)		31.7 (19–50)	31.8 (21–49)
Pathological diagnosis 1–4 years later	CIN3+	210 (100%)	-
Pathological diagnosis 1–4 years later	No CIN3+	-	218 (100%)

^a,bAll cytology-positive and cytology-negative samples were hrHPV-positive apart from 5 hrHPV-negative samples and 1 unknown in the discovery set and 5 hrHPV-negative samples in the diagnostic validation set. In the predictive validation set, 10 samples (out of 428) were hrHPV-negative

ISSN: 1756-994X