Table 2 Sensitivity (detection of CIN2 or CIN3 and invasive cancers) of the WID-CIN test at different levels of specificity (CIN1 or normal cytology) and age groups in the diagnostic validation set. All three invasive cancers had a WID-CIN index value above the 90% specificity cutoff

Specificity (≤CIN1) at 50%

All ages

−0.53

75.6% (66.7–84.4) [68/90]

96.6% (92.7–100) [84/87]

< 30 years

−0.56

70.6% (55.3–85.9) [24/34]

96.9% (90.8–100) [31/32]

≥ 30 years

−0.49

73.2% (61.6–84.8) [41/56]

96.4% (91.4–100) [53/55]

Specificity (≤CIN1) at 75%

All ages

−0.34

54.4% (44.2–64.7) [49/90]

89.7% (83.3–96.1) [78/87]

< 30 years

−0.17

35.3% (19.2–51.4) [12/34]

65.6% (49.2–82.1) [21/32]

≥ 30 years

−0.33

55.4% (42.3–68.4) [31/56]

92.7% (85.9–99.6) [51/55]

Specificity (≤CIN1) at 90%

All ages

−0.16

38.9% (28.8–49) [35/90]

78.2% (69.5–86.8) [68/87]

< 30 years

−0.06

23.5% (9.3–37.8) [8/34]

50% (32.7–67.3) [16/32]

≥ 30 years

−0.21

44.6% (31.6–57.7) [25/56]

87.3% (78.5–96.1) [48/55]