Fig. 1From: CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer researchThe workflow diagram for CTpathway. a GPCM and crosstalk effect matrix construction. GPCM was constructed by integrating pathway, TF regulation, and PPI information. Then, we evaluated the crosstalk effects in GPCM by applying the multi-RWR algorithm to calculate a crosstalk effect matrix C. b Gene differential expression (DE) score calculation. We integrated FC and P-value to calculate DE scores. Next, risk score (RS) for each gene and pathway score (PS) for each pathway were calculated to identify the significant risk pathways. c Visualization of significant pathways by bar graph, bubble plot, and enrichment mapBack to article page