Fig. 1

Study scheme. A A literature search was used to compose a list of oncomarkers for single-cell quantification (left panel). Selected cell-surface oncoproteins were quantified using multicolor FACS (right panel). B SA was extended to single cells to identify distinct subpopulations based on sets of unbalanced processes (cell-specific signaling signatures, CSSS, right panel). C To validate the hypothesis that targeting evolving cellular subpopulations in response to RT would enhance TNBC RT sensitization, a series of in vitro and in vivo experiments, using TNBC patient-derived and mice models, were performed