Fig. 3

The ECM-High matreotype is associated with poor prognosis. A Gene expression heatmap of core matrisomal genes differentially expressed between tumor and non-tumor tissue illustrating the three major matreotypes (ECM-Low, Non-Tumor, and ECM-High) identified by consensus clustering. B,C ECM-specific signatures assigned to the three matreotypes reveal ECM-High and ECM-Low matreotypes compared with non-tumor (NT) matreotype for the KEGG ECM (B, ECM-Low vs ECM-High p <2.2E−16, NT-Like vs ECM-High p=0.27, ECM-Low vs NT-Like p=1.3E−10, Mann-Whitney U test) and Reactome ECM degradation pathways (C, ECM-Low vs ECM-High p<2.2E−16, NT-Like vs ECM-High p=0.011, ECM-Low vs NT-Like p=1.3E−7, Mann-Whitney U test). D,E Disease-specific survival of tumors corresponding to the ECM-High (blue) and ECM-Low (green) matreotypes in the TCGA (D, ECM-Low n=73; ECM-High n=107; Log-rank p=0.0055, Cox proportional hazards model HR (95% confidence interval)= 1.97 (1.21–3.22) of ECM-High compared with reference ECM-Low; multivariate model with age and stage covariates HR = 1.92 (1.17–3.17) p=0.010) and NCI-MD cohorts (E, ECM-Low n=14, ECM-High n=16; Log-rank p=0.050, Cox proportional hazards model HR (95% confidence interval)= 3.43 (0.99–12.72); multivariate model with stage covariate HR = 1.47 (1.01–18.55) p=0.048)