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Fig. 7 | Genome Medicine

Fig. 7

From: Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma

Fig. 7

The poor-prognosis matreotype overlaps with ECM remodeling in idiopathic pulmonary fibrosis. A,B ECM genes that act as ligands for the PDGFRB (A, p=3.7E−15) and FLT4 (B, p=8.3E−31) receptors in the ECM-High and ECM-Low matreotypes; Mann-Whitney U test. C Ligand-receptor interactions between core matrisome genes differentially expressed between ECM-High and ECM-Low matreotypes and the fibrogenic receptors FLT4 and PDGFRB. D IPF fibrosis score in the ECM-Low (blue), ECM-High (green), and non-tumor (yellow) matreotypes; ECM-High vs ECM-Low p<2.2E−16, ECM-High vs Non-tumor p=3.3E−11, ECM-Low vs Non-tumor p=2.8E−9, Mann-Whitney U test. E Estimated abundance of IPF-specific CTHRC1+ fibroblasts in the ECM-Low (blue), ECM-High (green), and non-tumor (yellow) matreotypes; ECM-High vs ECM-Low p=4.1E−20, ECM-High vs Non-tumor p=0.0011, ECM-Low vs Non-tumor p=1.0, Mann-Whitney U test. F IPF Aberrant basaloid score in the ECM-Low (blue), ECM-High (green), and non-tumor (yellow) matreotypes (ECM-High vs ECM-Low p=8.9E−19, ECM-High vs Non-tumor p=0.0062, ECM-Low vs Non-tumor p=0.0056), Mann-Whitney U test

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