Fig. 1

Generation of PDX models and patient treatment histories. A Graphical overview of PDX collection and analysis. Samples were obtained by surgical resection (pleurectomy/decortication), biopsy, and aspirations. Both PDX and human samples were analyzed by IHC, targeted next generation sequencing (MSK-IMPACT), and histologic subtyping when material was available. RNA sequencing was performed on all PDX models with available data. The “n” represents the number of samples run at each step of the analysis. B Swimmers plot showing the clinical course of all 22 patients where the red arrow denotes the time of tissue collection for the PDX and C details of systemic therapy received prior to PDX collection in the 11 applicable patients. E, epithelioid; B, biphasic; S, sarcomatoid