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Table 2 Histologic subtyping of available patient samples and PDX models

From: Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library

Patient ID

Histology

Epithelioid subtyping

(E/B/S)

Predominant architecture

All patterns present

Nuclear grade (Kadota/MSKCC)

Patient

PDX

Patient

PDX

Patient

PDX

Patient

PDX

Epithelioid

MSK_LX282

E

E

Trabecular

Trabecular

T

T, S

I

I

MSK_LX627

E

E

Trabecular

Trabecular

T

S

II

II

MSK_LX703A

E

NA

Tubulopapillary

NA

S, MP, TP

NA

II

NA

MSK_LX13

E

NA

Solid

NA

S, P*

NA

II

NA

MSK_LX606

E

E

Solid

Solid

S, TP

S, T

II

II

MSK_LX333

E

E

Tubulopapillary

Solid

TP, MP, S

S

III

III

MSK_LX590

E

E

Solid

Solid

S, TP

S, TP

III

III

MSK_LX678

E

E

Solid

Solid

S

S

III

III

MSK_LX154

E

E

Solid

Solid

S

S

I

II

MSK_LX413

E

E

Trabecular

Solid

T, S, TP

S, T

II

III

MSK_LX570

E

E

Solid

Solid

S, T

S

II

III

MSK_LX944B

E

E

Tubulopapillary

Solid

TP, T, S

S

II

II

MSK_LX892

E

NA

Tubulopapillary

NA

TP

NA

I

NA

MSK_LX19

E

NA

Solid

NA

S

NA

III

NA

MSK_LX96

E

E

Trabecular

Solid

T, S, TP

S

III

II

  1. Comparative histologic subtyping for the patient (n = 22) and PDX TMA samples (n = 16) with available tissue. For the 15 patient samples with epithelioid histology, the predominant architecture, all architectural patterns/cytologic features present, and nuclear grades were annotated and compared to the 11 available PDX specimens
  2. E epithelioid, B biphasic, S sarcomatoid, PDX patient derived xenograft, MSKCC Memorial Sloan Kettering Cancer Center, Trabecular [T]; Tubulopapillary [TP]; Solid [S]; Micropapillary [MP]; Pleomorphic [P]; not applicable [NA]
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Genome Medicine

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