Fig. 4

A high Alzheimer’s disease genetic risk increases the Parkinson’s disease severity risk. a The most influential Axis (Axis 1) is associated with the genetic risk of Alzheimer’s disease The proportion of phenotypic variation explained by the first phenotypic axis derived using these different disease risks (we considered here genome-wide association (GWA) p-value < 0.1) as compared to the original phenotypic axes or exceeding significantly the original phenotypic axis 1 derived using the entire genotype (black horizontal line) or random SNP set respectively (black horizontal line) within Oxford Discovery cohort The colour represent the category of traits: neurodegenerative, neuropsychiatric, metabolic, autoimmune and anthropometric. b The Axis 1 is specifically associated with a biomarker strongly associated with future conversion to dementia In the PPMI cohort, PD patients with higher score for the Phenotypic axis 1 (x-axis), have significant lower CSF level Aβ1–42 (y-axis), a biomarker strongly associated with future conversion to dementia. c The Axis 1 is associated with rapid form of Parkinson’s disease. Boxplot comparing the accuracy of PHENIX to predict the progression of different clinical phenotypes with a general relatedness genetics matrix (blue vs a genetic relatedness matrix calculated by using Alzheimer's disease's genetics variants with GWA p < 0.05 (yellow) in the Oxford Discovery, Tracking UK and PPMI cohort