Fig. 3
From: Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex
Trans-eQTL hotspots. A Trans-eQTL hotspots represent trans-eSNPs that exhibit associations with at least three trans-eGenes. B Trans-eGenes associated with a shared trans-eSNP tend to be co-regulated. C Examples of trans-eQTL hotspots. The cis-eGenes are shown in orange boxes, and their respective trans-eGenes are shown in blue boxes. The red triangles are used to schematically designate the proximal relationship between the cis-eSNP and cis-eGene. D Cell-type-specific TF-target gene relationships detected by our mediator-candidate-trans-cis-QTL network